Peptide Libraray

Figainin 1

General Information

DCTPep ID DCTPep01020

Peptide Name Figainin 1

Sequence FIGTLIPLALGALTKLFK

Sequence Length 18

UniProt ID A0A2L2DDE6

PubChem CID Not available

Origin B. raniceps skin secretion

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
B16-F10	Mouse melanoma	IC50=10.5 µM (0.020 g/L)	MTT assay	24h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50=11.1 µM (0.021 g/L)	MTT assay	24h	1
MCF-7	Invasive breast carcinoma of no special type	IC50=13.7 µM (0.026 g/L)	MTT assay	24h	1

Hemolytic Activity Human red blood cells: HC50 =10 µM (0.019 g/L) (testing time is 24 h)

Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=13 µM (0.025 g/L) (testing time is 24 h)

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01020

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C95H158N20O21

Absent amino acids CDEHMNQRSVWY

Theoretical pI 10.00

Acidic residues 0

Basic residues 2

Polar residues 4

Molecular weight (Average) 1916.42

Molecular weight (Monoisotopic) 1915.19

Common amino acids L

Net charge 2

Instability index (II) -14.66

Aliphatic index 162.78

Grand average of hydropathicity (GRAVY) 1.422

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 32967114

Title Figainin 1, a Novel Amphibian Skin Peptide with Antimicrobial and Antiproliferative Properties

Doi 10.3390/antibiotics9090625

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available