This work is licensed under a Creative Commons Attribution 4.0 International License.
vCPP 2319
General Information
DCTPep ID DCTPep01028
Peptide Name vCPP 2319
Sequence WRRRYRRWRRRRRWRRRPRR
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | IC50=5.02±1.04 µM | CellTiter-Blue assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>200µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01028
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C137H228N68O22
Absent amino acids ACDEFGHIKLMNQSTV
Theoretical pI 12.81
Acidic residues 0
Basic residues 15
Polar residues 1
Molecular weight (Average) 3179.76
Molecular weight (Monoisotopic) 3177.88
Common amino acids R
Net charge 15
Instability index (II) 346.81
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -3.655
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 17990
Abs 0.1% (=1 g/l) 5.658
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33015016
Title To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.