Orc1

General Information


DCTPep ID  DCTPep01030

Peptide Name   Orc1

Sequence  RRIPFWPPNLPGPRRPPWFLPDFRIPRIPRKR

Sequence Length  32

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MEC-1 Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia 40% Killing=32µM MTT assay 20h 1

Hemolytic Activity  Human erythrocytes:0% Hemolysis=32µM

Normal (non-cancerous) Cytotoxicity  HaCat: 15% Killing=32µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01030

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C193H296N60O36

Absent amino acids  ACEHMQSTVY

Theoretical pI  12.48

Acidic residues  1

Basic residues  9

Polar residues  2

Molecular weight (Average)  4032.85

Molecular weight (Monoisotopic)  4030.32

Common amino acids  P

Net charge  8

Instability index (II)  76.41

Aliphatic index  60.94

Grand average of hydropathicity (GRAVY)  -1.113

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 2.728

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33036159

Title  Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens

Doi 10.3390/ijms21197367

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.