Peptide Libraray

Cathelicidin-like peptide Lip1

General Information

DCTPep ID DCTPep01033

Peptide Name Cathelicidin-like peptide Lip1

Sequence RRIRIRPPRLPRPRPRPWFPPRFPIPRIPGKR

Sequence Length 32

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MEC-1	Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia	90% killing=32μM	MTT assay	20h	1

Hemolytic Activity Human erythrocytes:0% Hemolysis=32µM

Normal (non-cancerous) Cytotoxicity HaCat: 10% Killing=32µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01033

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C188H309N67O33

Absent amino acids ACDEHMNQSTVY

Theoretical pI 13.00

Acidic residues 0

Basic residues 12

Polar residues 1

Molecular weight (Average) 4035.95

Molecular weight (Monoisotopic) 4033.46

Common amino acids PR

Net charge 12

Instability index (II) 72.45

Aliphatic index 60.94

Grand average of hydropathicity (GRAVY) -1.403

Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.363

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33036159

Title Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens

Doi 10.3390/ijms21197367

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available