HS1

General Information


DCTPep ID  DCTPep01042

Peptide Name   HS1

Sequence  CGAISLAPKAQIKES

Sequence Length  15

UniProt ID  Q15116 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
CT26 Mouse colon adenocarcinoma IC50=19.2±2.3 µM MTT assay 24, 48, 72h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  programmed cell death protein 1

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01042

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C65H114N18O21S1

Absent amino acids  DFHMNRTVWY

Theoretical pI  8.20

Acidic residues  1

Basic residues  2

Polar residues  4

Molecular weight (Average)  1515.79

Molecular weight (Monoisotopic)  1514.81

Common amino acids  A

Net charge  1

Instability index (II)  23.69

Aliphatic index  98.00

Grand average of hydropathicity (GRAVY)  0.153

Half Life 
  1.2 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33360579

Title  Design, synthesis and evaluation of PD-L1 peptide antagonists as new anticancer agents for immunotherapy

Doi 10.1016/j.bmc.2020.115951

Year  2021

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.