This work is licensed under a Creative Commons Attribution 4.0 International License.
HS4
General Information
DCTPep ID DCTPep01046
Peptide Name HS4
Sequence GAISLAPKLQINE
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| CT26 | Mouse colon adenocarcinoma | IC50=5.6±0.15 µM | MTT assay | 24, 48, 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target programmed cell death protein 1
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01046
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C60H104N16O19
Absent amino acids CDFHMRTVWY
Theoretical pI 6.00
Acidic residues 1
Basic residues 1
Polar residues 3
Molecular weight (Average) 1353.58
Molecular weight (Monoisotopic) 1352.77
Common amino acids AIL
Net charge 0
Instability index (II) 36.06
Aliphatic index 135.38
Grand average of hydropathicity (GRAVY) 0.231
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33360579
Title Design, synthesis and evaluation of PD-L1 peptide antagonists as new anticancer agents for immunotherapy
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.