This work is licensed under a Creative Commons Attribution 4.0 International License.
MSSV
General Information
DCTPep ID DCTPep01048
Peptide Name MSSV
Sequence XVXFL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Fusarium spp. isolated from Korean potato
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| 5637 | Bladder carcinoma | IC50=20 μg/mL | MTT assay | 24h | 1 |
| T24 | Bladder carcinoma | IC50=20 μg/mL | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism MSSV inhibited the proliferation of both bladder cancer 5637 and T24 cells, which was attributed to the G1-phase cell cycle arrest, apoptosis induction, and alteration of mitogen-activated protein kinases (MAPKs) and protein kinase b (AKT) signaling pathways.
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond X1<--->Leu5
N-terminal Modification None
C-terminal Modification None
Other Modification X1=leucic acid component; X3=N-methylleucine;
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33430488
Title N-Methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus fusarium
Doi 10.1016/s0031-9422(00)00280-6
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.