This work is licensed under a Creative Commons Attribution 4.0 International License.
LvHemB1
General Information
DCTPep ID DCTPep01051
Peptide Name LvHemB1
Sequence DVNFLLHKIYGNIRY
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Litopenaeus vannamei
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| EC109 | Esophageal cancer | 49.01% decrease=50μg/mL | MTS assay | 24h | 1 |
| HepG2 | Hepatoblastoma | 53.26% decrease=50μg/mL | MTS assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 70.30% decrease=50μg/mL | MTS assay | 24h | 1 |
| EJ | Bladder carcinoma | 78.44% decrease=50μg/mL | MTS assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity THLE-3: 30.83% decrease=50μg/mL
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01051
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C88H133N23O22
Absent amino acids ACEMPQSTW
Theoretical pI 8.50
Acidic residues 1
Basic residues 3
Polar residues 5
Molecular weight (Average) 1865.16
Molecular weight (Monoisotopic) 1864
Common amino acids ILNY
Net charge 2
Instability index (II) 22.39
Aliphatic index 123.33
Grand average of hydropathicity (GRAVY) -0.100
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.598
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33630204
Title LvHemB1, a novel cationic antimicrobial peptide derived from the hemocyanin of Litopenaeus vannamei, induces cancer cell death by targeting mitochondrial voltage-dependent anion channel 1
Doi 10.1007/s10565-021-09588-y
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.