Peptide Libraray

Dermaseptin S4 (1-28)a

General Information

DCTPep ID DCTPep01052

Peptide Name Dermaseptin S4 (1-28)a

Sequence ALWMTLLKKVLKAAAKAALNAVLVGANA

Sequence Length 28

UniProt ID P80280

PubChem CID Not available

Origin Phyllomedusa sauvagii

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SW620	Colon adenocarcinoma	44.76±23.77% Cytotoxicity=256 µg/ml	MTT assay	3h	1

Hemolytic Activity Human erythrocytes: 68.5±10.83% Hemolysis=256 µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01052

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C132H229N35O32S1

Absent amino acids CDEFHIPQRSY

Theoretical pI 10.48

Acidic residues 0

Basic residues 4

Polar residues 4

Molecular weight (Average) 2850.55

Molecular weight (Monoisotopic) 2848.71

Common amino acids A

Net charge 4

Instability index (II) 10.37

Aliphatic index 146.79

Grand average of hydropathicity (GRAVY) 1.032

Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.929

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33774792

Title Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620

Doi 10.1007/s11356-021-13683-2 Abstract

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_18029