Peptide Libraray

Dermaseptin S4 (5-28)a

General Information

DCTPep ID DCTPep01053

Peptide Name Dermaseptin S4 (5-28)a

Sequence TLLKKVLKAAAKAALNAVLVGANA

Sequence Length 24

UniProt ID P80280

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SW620	Colon adenocarcinoma	70.84±14.6% Cytotoxicity=256 µg/ml	MTT assay	3h	1

Hemolytic Activity Human erythrocytes: 57.1±7.64% Hemolysis=256 µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01053

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C107H194N30O28

Absent amino acids CDEFHIMPQRSWY

Theoretical pI 10.48

Acidic residues 0

Basic residues 4

Polar residues 4

Molecular weight (Average) 2348.9

Molecular weight (Monoisotopic) 2347.47

Common amino acids A

Net charge 4

Instability index (II) -8.1

Aliphatic index 150.83

Grand average of hydropathicity (GRAVY) 0.929

Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33774792

Title Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620

Doi 10.1007/s11356-021-13683-2 Abstract

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_18034