This work is licensed under a Creative Commons Attribution 4.0 International License.
Dermaseptin S4 (1-28)
General Information
DCTPep ID DCTPep01054
Peptide Name Dermaseptin S4 (1-28)
Sequence ALWMTLLKKVLKAAAKAALNAVLVGANA
Sequence Length 28
UniProt ID P80280
PubChem CID 16130878
Origin Phyllomedusa sauvagii
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SW620 | Colon adenocarcinoma | 66.5±5.32% Cytotoxicity=256 µg/ml | MTT assay | 3h | 1 |
Hemolytic Activity Human erythrocytes: 80±3.32% Hemolysis=256 µg/ml
Normal (non-cancerous) Cytotoxicity BHK-21 BSR: 12% Cytotoxicity=10 µM; Vero cells: 50% Cytotoxicity=7.50 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01054
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C132H229N35O32S1
Absent amino acids CDEFHIPQRSY
Theoretical pI 10.48
Acidic residues 0
Basic residues 4
Polar residues 4
Molecular weight (Average) 2850.55
Molecular weight (Monoisotopic) 2848.71
Common amino acids A
Net charge 4
Instability index (II) 10.37
Aliphatic index 146.79
Grand average of hydropathicity (GRAVY) 1.032
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.929
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33774792
Title Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620
Doi 10.1007/s11356-021-13683-2 Abstract
Year 2021
Literature 2
Pubmed ID 29439871
Title Dermaseptins as potential antirabies compounds
Doi 10.1016/j.vaccine.2018.01.066
Year 2019
Literature 3
Pubmed ID 23161023
Title In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.