Dermaseptin S4 (1-28)

General Information


DCTPep ID  DCTPep01054

Peptide Name   Dermaseptin S4 (1-28)

Sequence  ALWMTLLKKVLKAAAKAALNAVLVGANA

Sequence Length  28

UniProt ID  P80280 

PubChem CID  16130878 

Origin  Phyllomedusa sauvagii

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
SW620 Colon adenocarcinoma 66.5±5.32% Cytotoxicity=256 µg/ml MTT assay 3h 1

Hemolytic Activity  Human erythrocytes: 80±3.32% Hemolysis=256 µg/ml

Normal (non-cancerous) Cytotoxicity  BHK-21 BSR: 12% Cytotoxicity=10 µM; Vero cells: 50% Cytotoxicity=7.50 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01054

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C132H229N35O32S1

Absent amino acids  CDEFHIPQRSY

Theoretical pI  10.48

Acidic residues  0

Basic residues  4

Polar residues  4

Molecular weight (Average)  2850.55

Molecular weight (Monoisotopic)  2848.71

Common amino acids  A

Net charge  4

Instability index (II)  10.37

Aliphatic index  146.79

Grand average of hydropathicity (GRAVY)  1.032

Half Life 
  4.4 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 1.929

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33774792

Title  Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620

Doi 10.1007/s11356-021-13683-2 Abstract

Year  2021

Literature 2

Pubmed ID 29439871

Title  Dermaseptins as potential antirabies compounds

Doi 10.1016/j.vaccine.2018.01.066

Year  2019

Literature 3

Pubmed ID 23161023

Title  In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2

Doi 10.1002/jmv.23450

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.