Peptide Libraray

PTN

General Information

DCTPep ID DCTPep01059

Peptide Name PTN

Sequence ILGTILGLLKGL

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin venom glands of three different wasps

Type Native peptide

Classification

ACP Tumor active peptide Cancer targeted peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MDA-MB-231	Breast adenocarcinoma	CC50=15.9±1.1 µM	MTT assay	24h	1

Hemolytic Activity hRBC(human blood red cells): CC50>>500 µM

Normal (non-cancerous) Cytotoxicity MCF-10A : CC50=96.8±3.5 µM (testing time is 24 h)

Target lipids

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C58H107N13O14

Absent amino acids ACDEFHMNPQRSVWY

Theoretical pI 8.75

Acidic residues 0

Basic residues 1

Polar residues 4

Molecular weight (Average) 1210.57

Molecular weight (Monoisotopic) 1209.81

Common amino acids L

Net charge 1

Instability index (II) 20.04

Aliphatic index 227.50

Grand average of hydropathicity (GRAVY) 1.850

Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 34090029

Title Protonectin peptides target lipids, act at the interface and selectively kill metastatic breast cancer cells while preserving morphological integrity

Doi 10.1016/j.jcis.2021.05.115

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available