Peptide Libraray

LK-13

General Information

DCTPep ID DCTPep01063

Peptide Name LK-13

Sequence CLLKKLLKKLLKK

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin AMP

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HCT 116	Colon carcinoma	IC50=23±2 µM	MTT assay	72h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50=83±9 µM	MTT assay	72h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HDF: IC50>100 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01063

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C75H145N19O14S1

Absent amino acids ADEFGHIMNPQRSTVWY

Theoretical pI 10.32

Acidic residues 0

Basic residues 6

Polar residues 1

Molecular weight (Average) 1569.16

Molecular weight (Monoisotopic) 1568.09

Common amino acids KL

Net charge 6

Instability index (II) -8.61

Aliphatic index 180.00

Grand average of hydropathicity (GRAVY) 0.146

Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 34509120

Title Rationally designed short cationic α-helical peptides with selective anticancer activity

Doi 10.1016/j.jcis.2021.08.200

Year 2022

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available