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PCC-1
General Information
DCTPep ID DCTPep01065
Peptide Name PCC-1
Sequence KKRKKKAFALKFVVDLI
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin insect-derived peptide
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SK-MEL-28 | Cutaneous melanoma | IC50=50.8 µM | MTT assay | 24, 48h | 1 |
| G-361 | Melanoma | IC50=57.8 µM | MTT assay | 24, 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HaCaT: not induce toxicity
Target Not available
Affinity Not available
Mechanism PCC-1 induces cell proliferation inhibition, apoptosis, and cell cycle arrest by downregulating Sp1 expression in the melanoma cell lines SK-MEL-28 and G361.
Structure Information
PDB ID Not available
Predicted Structure DCTPep01065
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C98H170N26O20
Absent amino acids CEGHMNPQSTWY
Theoretical pI 10.68
Acidic residues 1
Basic residues 7
Polar residues 0
Molecular weight (Average) 2032.59
Molecular weight (Monoisotopic) 2031.31
Common amino acids K
Net charge 6
Instability index (II) 14.75
Aliphatic index 114.71
Grand average of hydropathicity (GRAVY) -0.100
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34531430
Title Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways
Doi 10.1007/s10989-021-10288-8
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.