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C-ori
General Information
DCTPep ID DCTPep01066
Peptide Name C-ori
Sequence VTFVLIAAK
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Cordyceps militaris
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HT-29 | Colon adenocarcinoma | IC50=114.9±1.5 µM | MTT assay | 24, 48, 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C47H80N10O11
Absent amino acids CDEGHMNPQRSWY
Theoretical pI 8.72
Acidic residues 0
Basic residues 1
Polar residues 1
Molecular weight (Average) 961.21
Molecular weight (Monoisotopic) 960.6
Common amino acids AV
Net charge 1
Instability index (II) 13.17
Aliphatic index 173.33
Grand average of hydropathicity (GRAVY) 2.056
Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34641308
Title Virtual Screening for Biomimetic Anti-Cancer Peptides from Cordyceps militaris Putative Pepsinized Peptidome and Validation on Colon Cancer Cell Line
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.