LKLK
General Information
DCTPep ID DCTPep01070
Peptide Name LKLK
Sequence LKLKLKLKLKLK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin cationic amphiphilic peptides
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
HCT 116 | Colon carcinoma | IC50=14.5±1.3 µM | MTT assay | 72h | 1 |
HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=17.7±6.5 µM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HDF: IC50>40 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C72H140N18O13
Absent amino acids ACDEFGHIMNPQRSTVWY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 1466.02
Molecular weight (Monoisotopic) 1465.08
Common amino acids KL
Net charge 6
Instability index (II) -68.66
Aliphatic index 195.00
Grand average of hydropathicity (GRAVY) -0.050
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34715505
Title Correlation between the secondary structure and surface activity of β-sheet forming cationic amphiphilic peptides and their anticancer activity
Doi 10.1016/j.colsurfb.2021.112165
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available