Peptide Libraray

LRLK

General Information

DCTPep ID DCTPep01072

Peptide Name LRLK

Sequence LRLKLRLKLRLK

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin cationic amphiphilic peptides

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HCT 116	Colon carcinoma	IC50>40 µM	MTT assay	72h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50>40 µM	MTT assay	72h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HDF: IC50=24.1±0.7 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C72H140N24O13

Absent amino acids ACDEFGHIMNPQSTVWY

Theoretical pI 12.31

Acidic residues 0

Basic residues 6

Polar residues 0

Molecular weight (Average) 1550.06

Molecular weight (Monoisotopic) 1549.1

Common amino acids L

Net charge 6

Instability index (II) 21.94

Aliphatic index 195.00

Grand average of hydropathicity (GRAVY) -0.200

Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 34715505

Title Correlation between the secondary structure and surface activity of β-sheet forming cationic amphiphilic peptides and their anticancer activity

Doi 10.1016/j.colsurfb.2021.112165

Year 2022

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available