LRLK

General Information


DCTPep ID  DCTPep01072

Peptide Name   LRLK

Sequence  LRLKLRLKLRLK

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  cationic amphiphilic peptides

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HCT 116 Colon carcinoma IC50>40 µM MTT assay 72h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma IC50>40 µM MTT assay 72h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HDF: IC50=24.1±0.7 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C72H140N24O13

Absent amino acids  ACDEFGHIMNPQSTVWY

Theoretical pI  12.31

Acidic residues  0

Basic residues  6

Polar residues  0

Molecular weight (Average)  1550.06

Molecular weight (Monoisotopic)  1549.1

Common amino acids  L

Net charge  6

Instability index (II)  21.94

Aliphatic index  195.00

Grand average of hydropathicity (GRAVY)  -0.200

Half Life 
  5.5 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 34715505

Title  Correlation between the secondary structure and surface activity of β-sheet forming cationic amphiphilic peptides and their anticancer activity

Doi 10.1016/j.colsurfb.2021.112165

Year  2022

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.