This work is licensed under a Creative Commons Attribution 4.0 International License.
SSTP1
General Information
DCTPep ID DCTPep01074
Peptide Name SSTP1
Sequence FLPLLISALTSLFPKLGK
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Skin Secretion of Indosylvirana aurantiaca
Type Native peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HSC-4 | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | IC50=10.22 μM | MTT assay | 48h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | IC50=4.5 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cell: SSTP1-induced hemolysis at 5 μM was only-0.25%
Normal (non-cancerous) Cytotoxicity HEK293: IC50=21.72 μM, lower cytotoxicity
Target IL6/IL6Rα/gp130 complex
Affinity Not available
Mechanism In IL6Rα-overexpressing cancer cells, SSTP1 induces apoptosis at low concentration through JNK pathway, without causing significant membrane disruption.
Structure Information
PDB ID Not available
Predicted Structure DCTPep01074
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C97H160N20O22
Absent amino acids CDEHMNQRVWY
Theoretical pI 10.00
Acidic residues 0
Basic residues 2
Polar residues 4
Molecular weight (Average) 1958.46
Molecular weight (Monoisotopic) 1957.2
Common amino acids L
Net charge 2
Instability index (II) 21.41
Aliphatic index 157.22
Grand average of hydropathicity (GRAVY) 1.167
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34867962
Title SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.