Peptide Libraray

MSI-136

General Information

DCTPep ID DCTPep01081

Peptide Name MSI-136

Sequence GIGKFLKKAKKFAKAFVKIINN

Sequence Length 22

UniProt ID Not available

PubChem CID Not available

Origin African clawed frog Xenopus laevis skin

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=10 µM	MTT assay	48 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism A mechanism which appears to be related to short duration non-receptor-driven contact with target cell membranes.

Structure Information

PDB ID Not available

Predicted Structure DCTPep01081

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C119H199N31O25

Absent amino acids CDEHMPQRSTWY

Theoretical pI 10.78

Acidic residues 0

Basic residues 7

Polar residues 4

Molecular weight (Average) 2464.08

Molecular weight (Monoisotopic) 2462.53

Common amino acids K

Net charge 7

Instability index (II) -7.2

Aliphatic index 97.73

Grand average of hydropathicity (GRAVY) 0.009

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 8319212

Title Anticancer efficacy of Magainin2 and analogue peptides

Doi Not available

Year 1993

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available