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P3
General Information
DCTPep ID DCTPep01088
Peptide Name P3
Sequence KWKLFKKIGIGAFLHSAKKF
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Ceropin A-Magainin 2
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| NCI-H146 | Lung small cell carcinoma; Small cell lung cancer | IC50=10.9 µM | MTT assay | 72 h | 1 |
| NCI-H128 | Lung small cell carcinoma; Small cell lung cancer | IC50=9.3 µM | MTT assay | 72 h | 1 |
| NCI-H69 | Lung small cell carcinoma; Small cell lung cancer | IC50=9.3 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Human red blood cells: hemolysis 0.1%(50 μg/mL); hemolysis 0.2%(100 μg/mL)
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01088
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C117H183N29O22
Absent amino acids CDEMNPQRTVY
Theoretical pI 10.70
Acidic residues 0
Basic residues 7
Polar residues 3
Molecular weight (Average) 2347.92
Molecular weight (Monoisotopic) 2346.41
Common amino acids K
Net charge 7
Instability index (II) -15
Aliphatic index 88.00
Grand average of hydropathicity (GRAVY) -0.025
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.342
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 9352466
Title Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 16 and cecropin A-melittin hybrid peptides
Doi 10.1111/j.1399-3011.1997.tb01469.x
Year 1997
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.