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DRS B3
General Information
DCTPep ID DCTPep01095
Peptide Name DRS B3
Sequence ALWKNMLKGIGKLAGQAALGAVKTLVGA
Sequence Length 28
UniProt ID P81485 P83641 C0HLD2
PubChem CID Not available
Origin Dermaseptins B
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Cytotoxicity=12 µM | Thymidine Incorporation assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01095
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C127H219N35O32S1
Absent amino acids CDEFHPRSY
Theoretical pI 10.48
Acidic residues 0
Basic residues 4
Polar residues 7
Molecular weight (Average) 2780.41
Molecular weight (Monoisotopic) 2778.63
Common amino acids A
Net charge 4
Instability index (II) -7.19
Aliphatic index 125.71
Grand average of hydropathicity (GRAVY) 0.657
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.978
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 9614066
Title Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics
Year 1998
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.