This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-ALa
General Information
DCTPep ID DCTPep01097
Peptide Name Temporin-ALa
Sequence FLPIVGKLLSGLSGLL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Amolops loloensis; Amolops jingdongensis; Amolops mantzorum
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HSC-4 | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | IC50>61.46 µM | MTT assay | Not available | 1 |
| SW620 | Colon adenocarcinoma | IC50>61.46 µM | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 25% Hemolysis=61.46 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01097
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C79H135N17O19
Absent amino acids ACDEHMNQRTWY
Theoretical pI 8.75
Acidic residues 0
Basic residues 1
Polar residues 5
Molecular weight (Average) 1627.04
Molecular weight (Monoisotopic) 1626.01
Common amino acids L
Net charge 1
Instability index (II) 0.19
Aliphatic index 188.75
Grand average of hydropathicity (GRAVY) 1.625
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Anticancer Activities of Antimicrobial BmKn2 Peptides Against Oral and Colon Cancer Cells
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.