This work is licensed under a Creative Commons Attribution 4.0 International License.
CPe-III(CPe-III-S)
General Information
DCTPep ID DCTPep01098
Peptide Name CPe-III(CPe-III-S)
Sequence RQSHFANAQP
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Chickpea (Cicer arietinum L.)
Type Native peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | EC50=1.50 μmol/mL | MTT assay | 72h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | EC50=2.38 μmol/mL | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target p53 protein
Affinity Not available
Mechanism the bioactive peptide combined the DNA binding domain of p53 protein by hydrogen bonds, induced the expression of p53 protein and facilitated its stability so that it inhibited the cell proliferation.
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C49H74N18O15
Absent amino acids CDEGIKLMTVWY
Theoretical pI 9.76
Acidic residues 0
Basic residues 2
Polar residues 2
Molecular weight (Average) 1155.24
Molecular weight (Monoisotopic) 1154.56
Common amino acids AQ
Net charge 2
Instability index (II) 81.09
Aliphatic index 20.00
Grand average of hydropathicity (GRAVY) -1.420
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Antioxidant activity and anti-proliferative effect of a bioactive peptide from chickpea (Cicer arietinum L.)
Doi 10.1016/j.foodres.2015.09.027
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.