Peptide Libraray

P19

General Information

DCTPep ID DCTPep01100

Peptide Name P19

Sequence SLPQNIPPLTQTPVVVPPF

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Synbiotic yoghurt

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HT-29	Colon adenocarcinoma	Antiproliferative acitivity (%)=38.55±1.75%, Peptide concentration 3 mg/mL	MTS assay	72h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01100

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C97H154N22O26

Absent amino acids ACDEGHKMRWY

Theoretical pI 5.24

Acidic residues 0

Basic residues 0

Polar residues 4

Molecular weight (Average) 2044.42

Molecular weight (Monoisotopic) 2043.14

Common amino acids P

Net charge 0

Instability index (II) 98.07

Aliphatic index 107.37

Grand average of hydropathicity (GRAVY) 0.274

Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Antioxidant peptides isolated from synbiotic yoghurt exhibit antiproliferative activities against HT-29 colon cancer cells

Doi 10.1016/j.idairyj.2016.08.003

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available