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P17
General Information
DCTPep ID DCTPep01101
Peptide Name P17
Sequence YQEPVLGPVRGPFPIIV
Sequence Length 17
PubChem CID Not available
Origin Synbiotic yoghurt
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HT-29 | Colon adenocarcinoma | Antiproliferative acitivity (%)=41.49±2.18%, Peptide concentration 3 mg/mL | MTS assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01101
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C91H141N21O22
Absent amino acids ACDHKMNSTW
Theoretical pI 6.00
Acidic residues 1
Basic residues 1
Polar residues 3
Molecular weight (Average) 1881.25
Molecular weight (Monoisotopic) 1880.06
Common amino acids P
Net charge 0
Instability index (II) 67.4
Aliphatic index 120.00
Grand average of hydropathicity (GRAVY) 0.482
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.792
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Antioxidant peptides isolated from synbiotic yoghurt exhibit antiproliferative activities against HT-29 colon cancer cells
Doi 10.1016/j.idairyj.2016.08.003
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.