This work is licensed under a Creative Commons Attribution 4.0 International License.
INKKI peptide
General Information
DCTPep ID DCTPep01103
Peptide Name INKKI peptide
Sequence INKKI
Sequence Length 5
UniProt ID Not available
PubChem CID Not available
Origin β-Casein
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=3.07 μg/mL | MTT assay | 24h | 1 |
| T-47D | Invasive breast carcinoma of no special type | IC50=3.26 μg/mL | MTT assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | IC50=3.53 μg/mL | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=3.78 µg/mL | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Fibroblast FN-1 (human): no effect (testing time is 24 h); Endothelial CRL 1730 (human) : no effect (testing time is 24 h)
Target Not available
Affinity Not available
Mechanism By apoptosis via mitochondrial pathway in a caspase-independent manner
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Evaluation of the antitumor and antiproliferative effects of the INKKI peptide on MCF-7 breast adenocarcinoma cells
Doi Not available
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.