Peptide Libraray

Hepcidin TH1-5

General Information

DCTPep ID DCTPep01104

Peptide Name Hepcidin TH1-5

Sequence GIKCRFCCGCCTPGICGVCCRF

Sequence Length 22

UniProt ID Not available

PubChem CID Not available

Origin Skin Secretion of the African Frog, Kassina senegalensis

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	IC50=20 μg/mL	MTT assay	72h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01104

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C94H153N29O24S8

Absent amino acids ADEHLMNQSWY

Theoretical pI 8.54

Acidic residues 0

Basic residues 3

Polar residues 13

Molecular weight (Average) 2329.91

Molecular weight (Monoisotopic) 2327.94

Common amino acids C

Net charge 3

Instability index (II) 12.79

Aliphatic index 48.64

Grand average of hydropathicity (GRAVY) 1.000

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 500
Abs 0.1% (=1 g/l) 0.215, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Hepcidin TH1-5 Induces Apoptosis and Activate Caspase-9 in MCF-7 Cells

Doi 10.7324/JAPS.2016.60211

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available