Peptide Libraray

Lycosin-II

General Information

DCTPep ID DCTPep01121

Peptide Name Lycosin-II

Sequence VWLSALKFIGKHLAKHQLSKL

Sequence Length 21

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HCT 116	Colon carcinoma	IC50=70.79 µg/mL	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity IC50 on PBMCs was = 92.0 ± 39.6 μM

Target Not available

Affinity Not available

Mechanism Lycosin-II Suppresses the Growth of Tumor Cells and Kills them Through Membrane Disruption and Apoptosis Induction

Structure Information

PDB ID Not available

Predicted Structure DCTPep01121

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C116H189N31O25

Absent amino acids CDEMNPRTY

Theoretical pI 10.48

Acidic residues 0

Basic residues 6

Polar residues 3

Molecular weight (Average) 2417.97

Molecular weight (Monoisotopic) 2416.45

Common amino acids L

Net charge 6

Instability index (II) 3.27

Aliphatic index 134.76

Grand average of hydropathicity (GRAVY) 0.271

Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.275

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Lycosin-II Suppresses the Growth of Tumor Cells and Kills them Through Membrane Disruption and Apoptosis Induction

Doi 10.1007/s10989-018-9736-3

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available