CMAP-L-24

General Information


DCTPep ID  DCTPep01129

Peptide Name   CMAP-L-24

Sequence  KKFFKKMKKLVKKFF

Sequence Length  15

UniProt ID  Not available

PubChem CID  Not available

Origin  Not available

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma At a concentration of 100μM, the 24 h cell viability is approximately 35%(Duncan-test,P<0.01) MTT assay 24 h Patent
ZR-75-1 Invasive breast carcinoma of no special type At a concentration of 100μM, the 24 h cell viability is approximately 41%(Duncan-test,P<0.01) MTT assay 24 h Patent
BT-474 Invasive breast carcinoma of no special type At a concentration of 100μM, the 24 h cell viability is approximately 50%(Duncan-test,P<0.01) MTT assay 24 h Patent
MCF-7 Invasive breast carcinoma of no special type At a concentration of 100μM, the 24 h cell viability is approximately 66%(Duncan-test,P<0.01) MTT assay 24 h Patent

Hemolytic Activity  Human red blood cells: no hemolytic activity at 12.5 μM, 25 μM, 50 μM, 100 μM

Normal (non-cancerous) Cytotoxicity  Less toxic than CDDP on human normal MCF10A and 293FT

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01129

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C100H163N23O16S1

Absent amino acids  ACDEGHINPQRSTWY

Theoretical pI  10.85

Acidic residues  0

Basic residues  8

Polar residues  0

Molecular weight (Average)  1975.6

Molecular weight (Monoisotopic)  1974.24

Common amino acids  K

Net charge  8

Instability index (II)  13.47

Aliphatic index  45.33

Grand average of hydropathicity (GRAVY)  -0.673

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID CN106831946A

Patent Title  Anticancer peptide as well as preparation method and application thereof  

Other Iinformation  Granted Patent; Family: 2s / 2ex; Family Jurisdictions: CN; Legal Status: Active; Application No: 201611198223; Filed: Dec 22, 2016; Published: Nov 10, 2020; Earliest Priority: Dec 22, 2016; Granted: Nov 10, 2020

Other Published ID  CN106831946B 




DCTPep is developed by Dr.Zheng's team.