This work is licensed under a Creative Commons Attribution 4.0 International License.
CMAP-L-233
General Information
DCTPep ID DCTPep01137
Peptide Name CMAP-L-233
Sequence KKKKFFMSFFFKKKF
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Not available
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | At a concentration of 100μM, the 24 h cell viability is approximately 72%(Duncan-test,P<0.01) | MTT assay | 24 h | Patent |
Hemolytic Activity Human red blood cells: no hemolytic activity at 12.5 μM, 25 μM, 50 μM, 100 μM
Normal (non-cancerous) Cytotoxicity Less toxic than CDDP on human normal MCF10A and 293FT
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01137
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C104H154N22O17S1
Absent amino acids ACDEGHILNPQRTVWY
Theoretical pI 10.78
Acidic residues 0
Basic residues 7
Polar residues 1
Molecular weight (Average) 2016.56
Molecular weight (Monoisotopic) 2015.16
Common amino acids K
Net charge 7
Instability index (II) 28.61
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -0.627
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN106831946A
Patent Title Anticancer peptide as well as preparation method and application thereof
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: CN; Legal Status: Active; Application No: 201611198223; Filed: Dec 22, 2016; Published: Nov 10, 2020; Earliest Priority: Dec 22, 2016; Granted: Nov 10, 2020
Other Published ID CN106831946B
This work is licensed under a Creative Commons Attribution 4.0 International License.