This work is licensed under a Creative Commons Attribution 4.0 International License.
v6Pep-2
General Information
DCTPep ID DCTPep01168
Peptide Name v6Pep-2
Sequence CNEWQLKSC
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Screen of phage display peptide library
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Kd=17.69 | CD44v6 specifically binds to assay | Not available | Patent |
| 4T1 | Malignant neoplasms of the mouse mammary gland | Kd=29.12 | CD44v6 specifically binds to assay | Not available | Patent |
| PANC-1 | Pancreatic ductal adenocarcinoma | Kd=6.655 | CD44v6 specifically binds to assay | Not available | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target CD44v6
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C46H71N13O15S2
Absent amino acids ADFGHIMPRTVY
Theoretical pI 5.99
Acidic residues 1
Basic residues 1
Polar residues 4
Molecular weight (Average) 1110.27
Molecular weight (Monoisotopic) 1109.46
Common amino acids C
Net charge 0
Instability index (II) 18.98
Aliphatic index 43.33
Grand average of hydropathicity (GRAVY) -0.811
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5625
Abs 0.1% (=1 g/l) 5.066, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 4.954, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID EP3733685A1
Patent Title Peptides Binding to Cd44v6 and Use Thereof
Other Iinformation Patent Application; Family: 6s / 7ex; Family Jurisdictions: EP, KR, US; Legal Status: Pending; Application No: 18889460; Filed: Dec 17, 2018; Published: Nov 4, 2020; Earliest Priority: Dec 15, 2017
Other Published ID EP3733685A4 KR102194025B1 KR20190072467A US2021163535A1
This work is licensed under a Creative Commons Attribution 4.0 International License.