v6Pep-2

General Information


DCTPep ID  DCTPep01168

Peptide Name   v6Pep-2

Sequence  CNEWQLKSC

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Screen of phage display peptide library

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma Kd=17.69 CD44v6 specifically binds to assay Not available Patent
4T1 Malignant neoplasms of the mouse mammary gland Kd=29.12 CD44v6 specifically binds to assay Not available Patent
PANC-1 Pancreatic ductal adenocarcinoma Kd=6.655 CD44v6 specifically binds to assay Not available Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  CD44v6

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C46H71N13O15S2

Absent amino acids  ADFGHIMPRTVY

Theoretical pI  5.99

Acidic residues  1

Basic residues  1

Polar residues  4

Molecular weight (Average)  1110.27

Molecular weight (Monoisotopic)  1109.46

Common amino acids  C

Net charge  0

Instability index (II)  18.98

Aliphatic index  43.33

Grand average of hydropathicity (GRAVY)  -0.811

Half Life 
  1.2 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5625
  Abs 0.1% (=1 g/l) 5.066, assuming all pairs of Cys residues form cystines
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 4.954, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID EP3733685A1

Patent Title  Peptides Binding to Cd44v6 and Use Thereof

Other Iinformation  Patent Application; Family: 6s / 7ex; Family Jurisdictions: EP, KR, US; Legal Status: Pending; Application No: 18889460; Filed: Dec 17, 2018; Published: Nov 4, 2020; Earliest Priority: Dec 15, 2017

Other Published ID  EP3733685A4  KR102194025B1  KR20190072467A  US2021163535A1 




DCTPep is developed by Dr.Zheng's team.