This work is licensed under a Creative Commons Attribution 4.0 International License.
HDH-LGBP-A2
General Information
DCTPep ID DCTPep01170
Peptide Name HDH-LGBP-A2
Sequence WLWKAIWKLLK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Not available
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | The non- survival rate in the HeLa cell it exposed to the HDH-LGBP-A2 peptide of the concentration of 10 μg/ml, 25 μg/ml, 50 μg/ml are 13%, 99%, 99% | MTS assay | 24 h | Patent |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | The non- survival rate in the HeLa cell it exposed to the HDH-LGBP-A2 peptide of the concentration of 10 μg/ml, 25 μg/ml, 50 μg/ml are 16%, 99%, 98% | MTS assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity In the concentration of 50 μg/ml, the normal cell (HUVEC) the viability was 47.9%
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C78H117N17O12
Absent amino acids CDEFGHMNPQRSTVY
Theoretical pI 10.30
Acidic residues 0
Basic residues 3
Polar residues 0
Molecular weight (Average) 1484.89
Molecular weight (Monoisotopic) 1483.91
Common amino acids KLW
Net charge 3
Instability index (II) 26.4
Aliphatic index 150.91
Grand average of hydropathicity (GRAVY) 0.300
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 11.112
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID KR101749548B1
Patent Title Antimicrobial Peptide Derived From Abalone Lipopolysaccharide and Beta-Glucan Binding Protein Nucleic Acid Encoding the Peptide and Uses Thereof
Other Iinformation Granted Patent; Family: 4s / 4ex; Family Jurisdictions: KR, JP; Legal Status: Active; Application No: 20150145265; Filed: Oct 19, 2015; Published: Jun 21, 2017; Earliest Priority: Oct 19, 2015; Granted: Jun 21, 2017
Other Published ID JP2017077236A JP6045678B1 KR101749548B1
This work is licensed under a Creative Commons Attribution 4.0 International License.