Peptide Libraray

HDH-LGBP-A1

General Information

DCTPep ID DCTPep01171

Peptide Name HDH-LGBP-A1

Sequence WLWKAIWKLLT

Sequence Length 11

UniProt ID Not available

PubChem CID Not available

Origin Not available

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	The non- survival rate in the HeLa cell it exposed to the HDH-LGBP-A1 peptide of the concentration of 10 μg/ml, 25 μg/ml, 50 μg/ml are 25%, 99%, 97%	MTS assay	24 h	Patent
HeLa	Human papillomavirus-related endocervical adenocarcinoma	The non- survival rate in the HeLa cell it exposed to the HDH-LGBP-A1 peptide of the concentration of 10 μg/ml, 25 μg/ml, 50 μg/ml are 35%, 99%, 95%	MTS assay	24 h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity In the concentration of 50 μg/ml, the normal cell (HUVEC) the viability was 32.8%

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C76H112N16O13

Absent amino acids CDEFGHMNPQRSVY

Theoretical pI 10.00

Acidic residues 0

Basic residues 2

Polar residues 1

Molecular weight (Average) 1457.82

Molecular weight (Monoisotopic) 1456.86

Common amino acids LW

Net charge 2

Instability index (II) 34.12

Aliphatic index 150.91

Grand average of hydropathicity (GRAVY) 0.591

Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 11.318

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID KR101749548B1

Patent Title Antimicrobial Peptide Derived From Abalone Lipopolysaccharide and Beta-Glucan Binding Protein Nucleic Acid Encoding the Peptide and Uses Thereof

Other Iinformation Granted Patent; Family: 4s / 4ex; Family Jurisdictions: KR, JP; Legal Status: Active; Application No: 20150145265; Filed: Oct 19, 2015; Published: Jun 21, 2017; Earliest Priority: Oct 19, 2015; Granted: Jun 21, 2017

Other Published ID JP2017077236A JP6045678B1 KR101749548B1