Peptide Libraray

p53 TAD(50-54)

General Information

DCTPep ID DCTPep01175

Peptide Name p53 TAD(50-54)

Sequence IEQWF

Sequence Length 5

UniProt ID Not available

PubChem CID Not available

Origin p53 protein

Type Native peptide

Classification

ACP Tumor active peptide Cancer targeted peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 100%, 90%, 82%, 23%	MTT assay	24 h	Patent
SNU-719	Gastric tubular adenocarcinoma	When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 100%, 95%, 82%, 10%	MTT assay	24 h	Patent
A549	Lung adenocarcinoma	When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 95%, 82%, 70%, 35%	MTT assay	24 h	Patent
HCT 116	Colon carcinoma	When the peptide concentrations were 1 μM, 10 μM, 100 μM, 300μM, the Cell viability(%) was 95%, 93%, 62%, 8%	MTT assay	24 h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target mdm2 (mouse double minute 2)

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID KR20050098766A

Patent Title Peptides for Inhibiting Mdm2 Function

Other Iinformation Patent Application; Family: 5s / 5ex; Family Jurisdictions: KR, US, WO; Legal Status: Inactive; Application No: 20050000931; Filed: Jan 5, 2005; Published: Oct 12, 2005; Earliest Priority: Apr 6, 2004; Granted: Dec 27, 2007

Other Published ID KR100788928B1 US2009030181A1 US8598127B2 WO2005097820A1