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Not available
General Information
DCTPep ID DCTPep01177
Peptide Name Not available
Sequence IKWKAILDAVKKVL
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Not available
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SK-OV-3 | Ovarian serous cystadenocarcinoma | It could confirm that the proliferation of the ovarian cancer cell was statistically carefully reduced in the culture medium containing the peptide of the concentration more than 25mM cultivated | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01177
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C79H137N19O17
Absent amino acids CEFGHMNPQRSTY
Theoretical pI 10.00
Acidic residues 1
Basic residues 4
Polar residues 0
Molecular weight (Average) 1625.07
Molecular weight (Monoisotopic) 1624.04
Common amino acids K
Net charge 3
Instability index (II) 8.86
Aliphatic index 167.14
Grand average of hydropathicity (GRAVY) 0.614
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.384
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID KR20160119943A
Patent Title Peptide has antimicrobial antifungal and antitumor activity and uses thereof
Other Iinformation Patent Application; Family: 2s / 2ex; Family Jurisdictions: KR; Legal Status: Active; Application No: 20150048678; Filed: Apr 6, 2015; Published: Oct 17, 2016; Earliest Priority: Apr 6, 2015; Granted: Dec 26, 2017
Other Published ID KR101810630B1
This work is licensed under a Creative Commons Attribution 4.0 International License.