Peptide Libraray

GW-Q4

General Information

DCTPep ID DCTPep01205

Peptide Name GW-Q4

Sequence GANAAKKFATIAKKFINYLW

Sequence Length 20

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
J5 [Human hepatocellular carcinoma]	Hepatocellular carcinoma	IC50=29.9 μM	MTT assay	24 h	Patent
Huh-7	Adult hepatocellular carcinoma; Adult hepatocellular carcinoma	IC50=70.0 μM	MTT assay	24 h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity NIH 3T3: As show in fig.3

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01205

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C109H167N27O25

Absent amino acids CDEHMPQRSV

Theoretical pI 10.18

Acidic residues 0

Basic residues 4

Polar residues 5

Molecular weight (Average) 2255.69

Molecular weight (Monoisotopic) 2254.26

Common amino acids A

Net charge 4

Instability index (II) 17.09

Aliphatic index 83.50

Grand average of hydropathicity (GRAVY) 0.075

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 3.099

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID TWI448297B

Patent Title A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity

Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014

Other Published ID Not available