GW-Q4

General Information


DCTPep ID  DCTPep01205

Peptide Name   GW-Q4

Sequence  GANAAKKFATIAKKFINYLW

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
J5 [Human hepatocellular carcinoma] Hepatocellular carcinoma IC50=29.9 μM MTT assay 24 h Patent
Huh-7 Adult hepatocellular carcinoma; Adult hepatocellular carcinoma IC50=70.0 μM MTT assay 24 h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  NIH 3T3: As show in fig.3

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01205

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C109H167N27O25

Absent amino acids  CDEHMPQRSV

Theoretical pI  10.18

Acidic residues  0

Basic residues  4

Polar residues  5

Molecular weight (Average)  2255.69

Molecular weight (Monoisotopic)  2254.26

Common amino acids  A

Net charge  4

Instability index (II)  17.09

Aliphatic index  83.50

Grand average of hydropathicity (GRAVY)  0.075

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 6990
  Abs 0.1% (=1 g/l) 3.099

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID TWI448297B

Patent Title  A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity

Other Iinformation  Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.