This work is licensed under a Creative Commons Attribution 4.0 International License.
GW-Q6
General Information
DCTPep ID DCTPep01210
Peptide Name GW-Q6
Sequence GIKIAKKAITIAKKIAKIYW
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | IC50=107.4 μM | MTT assay | 24 h | Patent |
| J5 [Human hepatocellular carcinoma] | Hepatocellular carcinoma | IC50=24.3 μM | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: As show in fig.3
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01210
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C110H189N27O23
Absent amino acids CDEFHLMNPQRSV
Theoretical pI 10.40
Acidic residues 0
Basic residues 6
Polar residues 3
Molecular weight (Average) 2257.88
Molecular weight (Monoisotopic) 2256.44
Common amino acids IK
Net charge 6
Instability index (II) -16.91
Aliphatic index 137.00
Grand average of hydropathicity (GRAVY) 0.375
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 3.096
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID TWI448297B
Patent Title A method of using novel synthetic peptides for the preparation of drugs with anti-liver cancer activity
Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: TW; Legal Status: Active; Application No: 99121957; Filed: Jul 5, 2010; Published: Aug 11, 2014; Earliest Priority: Jul 5, 2010; Granted: Aug 11, 2014
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.