This work is licensed under a Creative Commons Attribution 4.0 International License.
Penetratin, Antp, Sequence 3 from Patent US 20030077289
General Information
DCTPep ID DCTPep01237
Peptide Name Penetratin, Antp, Sequence 3 from Patent US 20030077289
Sequence RQIKIWFQNRRMKWKK
Sequence Length 16
UniProt ID P31256 Q28599 P31262 Q28600 P15860 P09636 P18865 P09637 P07548 P09077 P81192 Q24645 P02833 Q1KKX9 O13074 Q9PWD3 Q1KKX0 P09013 Q9IA23 P09014 Q1KL14 Q1KKY0 A2D5Y4 P20719 A2D5K9
PubChem CID 25242319
Origin Antennapedia homeodomain
Type Native peptide
Classification
ACP Tumor active peptide Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa WT | Human papillomavirus-related endocervical adenocarcinoma | 50% Cytotoxicity=281 ± 56.5 μM | MTS/PMS assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: HD50>128 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 1KZ0 2ND6 2NZZ 4XIC 1SAN 9ANT 1AHD 1HOM 2R5Y
Predicted Structure DCTPep01237
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C104H168N34O20S1
Absent amino acids ACDEGHLPSTVY
Theoretical pI 12.31
Acidic residues 0
Basic residues 7
Polar residues 1
Molecular weight (Average) 2246.75
Molecular weight (Monoisotopic) 2245.29
Common amino acids K
Net charge 7
Instability index (II) 46.6
Aliphatic index 48.75
Grand average of hydropathicity (GRAVY) -1.731
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 4.896
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23085001
Title Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure
Doi 10.1016/j.bbamem.2012.10.010
Year 2013
Patent
Patent ID US 2003/0077289 A1
Patent Title Use of cell-penetrating peptides to generate antitumor immunity.
Other Iinformation Granted Patent Family: 6s / 6ex; Family Jurisdictions: CN, WO, AU, US; Legal Status: Discontinued; Application No: 7755502; Filed:Feb 15, 2002; Published: Apr 24, 2003; Earliest Priority: Feb 15, 2001
Other Published ID CN1309417C CN1503628A WO2002064057A2 WO2002064057A3
External Code
DBAASP ID DBAASPS_6203
This work is licensed under a Creative Commons Attribution 4.0 International License.