Sequence 16 from Patent US 20100279918
General Information
DCTPep ID DCTPep01312
Peptide Name Sequence 16 from Patent US 20100279918
Sequence KETWFETWFTEWSQPKKKRKV
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic construct
Type Synthetic peptide
Classification
ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01312
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Not available
C-terminal Modification Not available
Other Modification None
Chiral L
Physicochemical Information
Formula C132H193N33O33
Absent amino acids ACDGHILMNY
Theoretical pI 9.82
Acidic residues 3
Basic residues 6
Polar residues 4
Molecular weight (Average) 2770.19
Molecular weight (Monoisotopic) 2768.44
Common amino acids K
Net charge 3
Instability index (II) 27.05
Aliphatic index 13.81
Grand average of hydropathicity (GRAVY) -1.686
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 5.956
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2010/0279918 A1
Patent Title Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents.
Other Iinformation Granted Patent Family: 7s / 7ex; Family Jurisdictions: DE, EP, WO, AT, US; Legal Status: Discontinued; Application No: 22536707; Filed:Mar 20, 2007; Published: Nov 4, 2010; Earliest Priority: Mar 20, 2006;
Other Published ID DE602007011901D1 EP1991586A1 EP1991586B1 WO2007108749A1 WO2007108749A8