Sequence 10 from Patent US 20100279918

General Information


DCTPep ID  DCTPep01315

Peptide Name   Sequence 10 from Patent US 20100279918

Sequence  MANLGYWLLALFVTMWTDVGLCKKRPKP

Sequence Length  28

UniProt ID  P04925 

PubChem CID  Not available

Origin  Mus sp.

Type  Native peptide

Classification

  

ACP



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01315

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Not available

Disulfide/Other Bond  Not available

N-terminal Modification  Not available

C-terminal Modification  Not available

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C153H239N37O35S3

Absent amino acids  EHIQS

Theoretical pI  9.63

Acidic residues  1

Basic residues  4

Polar residues  7

Molecular weight (Average)  3252.99

Molecular weight (Monoisotopic)  3250.72

Common amino acids  L

Net charge  3

Instability index (II)  16.12

Aliphatic index  97.50

Grand average of hydropathicity (GRAVY)  0.300

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 12490
  Abs 0.1% (=1 g/l) 3.840, assuming all pairs of Cys residues form cystines
  Ext. coefficient 12490
  Abs 0.1% (=1 g/l) 3.840, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US 2010/0279918 A1

Patent Title  Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents.

Other Iinformation  Granted Patent Family: 7s / 7ex; Family Jurisdictions: DE, EP, WO, AT, US; Legal Status: Discontinued; Application No: 22536707; Filed:Mar 20, 2007; Published: Nov 4, 2010; Earliest Priority: Mar 20, 2006;

Other Published ID  DE602007011901D1  EP1991586A1  EP1991586B1  WO2007108749A1  WO2007108749A8 




DCTPep is developed by Dr.Zheng's team.