This work is licensed under a Creative Commons Attribution 4.0 International License.
VEGFR2-Lytic
General Information
DCTPep ID DCTPep01359
Peptide Name VEGFR2-Lytic
Sequence ATWLPPRGGGKLlLKlLkkLLKlLKKK
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| BXPC-3 | Pancreatic ductal adenocarcinoma | IC50=12.2μM | WST-8 assay | 72h | Patent |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | IC50=3.5μM | WST-8 assay | 72h | Patent |
| T-47D | Invasive breast carcinoma of no special type | IC50=6.4μM | WST-8 assay | 72h | Patent |
| OE19 | Not available | IC50=7.1μM | WST-8 assay | 72h | Patent |
| LNCaP | Prostate carcinoma | IC50=8.9μM | WST-8 assay | 72h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK293: IC50>20μM; MRC-5:>20μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2011/0319336 A1
Patent Title Selective anticancer chimeric peptide.
Other Iinformation Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013
Other Published ID CN102238965A EP2370107A2 WO2010064207A2 WO2010064207A3
This work is licensed under a Creative Commons Attribution 4.0 International License.