Peptide Libraray

Sema3A(aa371-377) -nLytic

General Information

DCTPep ID DCTPep01366

Peptide Name Sema3A(aa371-377) -nLytic

Sequence GRVPYPRGGLLkLLKklLKKLlKL

Sequence Length 24

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Cancer targeted peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
BT-20	Invasive breast carcinoma of no special type	IC50=11.4μM	WST-8 assay	48h	Patent
PANC-1	Pancreatic ductal adenocarcinoma	IC50=14.1μM	WST-8 assay	48h	Patent
SKBR-3	Breast adenocarcinoma	IC50=14.5μM	WST-8 assay	48h	Patent
BXPC-3	Pancreatic ductal adenocarcinoma	IC50=14.7μM	WST-8 assay	48h	Patent
T-47D	Invasive breast carcinoma of no special type	IC50=3.7μM	WST-8 assay	48h	Patent
HuCC-T1	Intrahepatic cholangiocarcinoma; Cholangiocarcinoma	IC50=7.9μM	WST-8 assay	48h	Patent
SU.86.86	Pancreatic adenocarcinoma	IC50=8.0μM	WST-8 assay	48h	Patent
MDA-MB-231	Breast adenocarcinoma	IC50=8.1μM	WST-8 assay	48h	Patent
CFPAC-1	Cystic fibrosis; Pancreatic ductal adenocarcinoma; Cystic fibrosis	IC50=9.2μM	WST-8 assay	48h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Pancreatic epithelium: IC50>50μM; HEK293T: IC50>20μM

Target Epidermal growth factor receptor (EGFR)

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification l=D-Leucine; k=D-Lysine

Chiral Mix

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US8436137B2

Patent Title Selective anticancer chimeric peptide comprising an EGF receptor-binding peptide and a cytotoxic peptide

Other Iinformation Granted Patent; Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: May 7, 2013; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013

Other Published ID CN102238965A EP2370107A2 EP2370107B1 EP2370107B8 EP3228632A1 EP3228633A1 JP2010154842A JP2012510287A JP2015172050A JP5734865B2 JP5837712B2 US2013274200A1 US2013274201A1 US8436137B2 US8940862B2 US8940863B2 WO2010064207A2 WO2010064207A3