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IL4-lytic(L)
General Information
DCTPep ID DCTPep01377
Peptide Name IL4-lytic(L)
Sequence KQLIRFLKRLDRNGGGKLLLKLLKKLLKLLKKK
Sequence Length 33
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| BXPC-3 | Pancreatic ductal adenocarcinoma | IC50=3.2±0.4μM | WST-8 assay | 72h | Patent |
| U251 | Astrocytoma | IC50=3.7±0.1μM | WST-8 assay | 72h | Patent |
| A172 | Glioblastoma | IC50=3.8±1.1μM | WST-8 assay | 72h | Patent |
| KCCT873 | Not available | IC50=4.6±0.1μM | WST-8 assay | 72h | Patent |
| MDA-MB-231 | Breast adenocarcinoma | IC50=5.6±0.5μM | WST-8 assay | 72h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity PE: IC50>20μM; HEK293T: IC50=7.2±0.7μM; WI-38: IC50=9.8±0.8μM
Target Interleukin-4 (IL4) Receptor
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01377
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C184H338N54O38
Absent amino acids ACEHMPSTVWY
Theoretical pI 11.80
Acidic residues 1
Basic residues 13
Polar residues 4
Molecular weight (Average) 3915.05
Molecular weight (Monoisotopic) 3912.62
Common amino acids L
Net charge 12
Instability index (II) 5.4
Aliphatic index 153.64
Grand average of hydropathicity (GRAVY) -0.342
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2011/0319336 A1
Patent Title Selective anticancer chimeric peptide.
Other Iinformation Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013
Other Published ID CN102238965A EP2370107A2 WO2010064207A2 WO2010064207A3
This work is licensed under a Creative Commons Attribution 4.0 International License.