Sequence 20 from Patent US 20110319336

General Information


DCTPep ID  DCTPep01385

Peptide Name   Sequence 20 from Patent US 20110319336

Sequence  NYQWVPYQGRVPYPRGGGKLLLKLLKKLLKLLKKK

Sequence Length  35

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic construct

Type  Synthetic peptide

Classification

  

ACP



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01385

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Not available

Disulfide/Other Bond  Not available

N-terminal Modification  Not available

C-terminal Modification  Not available

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C199H331N53O42

Absent amino acids  ACDEFHIMST

Theoretical pI  10.63

Acidic residues  0

Basic residues  10

Polar residues  8

Molecular weight (Average)  4138.15

Molecular weight (Monoisotopic)  4135.54

Common amino acids  L

Net charge  10

Instability index (II)  2.46

Aliphatic index  116.86

Grand average of hydropathicity (GRAVY)  -0.551

Half Life 
  1.4 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 9970
  Abs 0.1% (=1 g/l) 2.409

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US 2011/0319336 A1

Patent Title  Selective anticancer chimeric peptide.

Other Iinformation  Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013

Other Published ID  CN102238965A  EP2370107A2  WO2010064207A2  WO2010064207A3 




DCTPep is developed by Dr.Zheng's team.