EB-lytic

General Information


DCTPep ID  DCTPep01403

Peptide Name   EB-lytic

Sequence  YHWYGYTPQNVIGGGKLlLKlLkkLLKlLKKK

Sequence Length  32

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
LNCaP Prostate carcinoma IC50=10±1.3μM WST-8 assay 72h Patent
BXPC-3 Pancreatic ductal adenocarcinoma IC50=12±0.9μM WST-8 assay 72h Patent
U251 Astrocytoma IC50=12±2.0μM WST-8 assay 72h Patent
SU.86.86 Pancreatic adenocarcinoma IC50=12±2.3μM WST-8 assay 72h Patent
BT-20 Invasive breast carcinoma of no special type IC50=6.5±0.7μM WST-8 assay 72h Patent
H322 Minimally invasive lung adenocarcinoma IC50=6.8±0.5μM WST-8 assay 72h Patent
H460 Lung large cell carcinoma IC50=8.9±1.6μM WST-8 assay 72h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  WI-38: IC50=46±2.7μM; MRC-5: 49±5.8μM; HEK293: IC50=44±2.8μM

Target  Epidermal growth factor receptor (EGFR)

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  l=D-Leucine; k=D-Lysine

Chiral  Mix



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US 2011/0319336 A1

Patent Title  Selective anticancer chimeric peptide.

Other Iinformation  Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013

Other Published ID  CN102238965A  EP2370107A2  WO2010064207A2  WO2010064207A3 




DCTPep is developed by Dr.Zheng's team.