Peptide Libraray

EB-lytic

General Information

DCTPep ID DCTPep01403

Peptide Name EB-lytic

Sequence YHWYGYTPQNVIGGGKLlLKlLkkLLKlLKKK

Sequence Length 32

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Cancer targeted peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
LNCaP	Prostate carcinoma	IC50=10±1.3μM	WST-8 assay	72h	Patent
BXPC-3	Pancreatic ductal adenocarcinoma	IC50=12±0.9μM	WST-8 assay	72h	Patent
U251	Astrocytoma	IC50=12±2.0μM	WST-8 assay	72h	Patent
SU.86.86	Pancreatic adenocarcinoma	IC50=12±2.3μM	WST-8 assay	72h	Patent
BT-20	Invasive breast carcinoma of no special type	IC50=6.5±0.7μM	WST-8 assay	72h	Patent
H322	Minimally invasive lung adenocarcinoma	IC50=6.8±0.5μM	WST-8 assay	72h	Patent
H460	Lung large cell carcinoma	IC50=8.9±1.6μM	WST-8 assay	72h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity WI-38: IC50=46±2.7μM; MRC-5: 49±5.8μM; HEK293: IC50=44±2.8μM

Target Epidermal growth factor receptor (EGFR)

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification l=D-Leucine; k=D-Lysine

Chiral Mix

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US 2011/0319336 A1

Patent Title Selective anticancer chimeric peptide.

Other Iinformation Granted Patent Family: 19s / 19ex; Family Jurisdictions: US, JP, EP, WO, CN; Legal Status: Active; Application No: 200913132580; Filed: Dec 3, 2009; Published: Dec 29, 2011; Earliest Priority: Dec 3, 2008; Granted: May 7, 2013

Other Published ID CN102238965A EP2370107A2 WO2010064207A2 WO2010064207A3