Peptide Libraray

Sequence 49 from Patent US 20120328692

General Information

DCTPep ID DCTPep01418

Peptide Name Sequence 49 from Patent US 20120328692

Sequence DWWPLAFEALLR

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin Synthetic construct

Type Synthetic peptide

Classification

ACP

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Not available

Disulfide/Other Bond Not available

N-terminal Modification Not available

C-terminal Modification Not available

Other Modification None

Chiral L

Physicochemical Information

Formula C75H105N17O17

Absent amino acids CGHIKMNQSTVY

Theoretical pI 4.37

Acidic residues 2

Basic residues 1

Polar residues 0

Molecular weight (Average) 1516.76

Molecular weight (Monoisotopic) 1515.79

Common amino acids L

Net charge -1

Instability index (II) 25.22

Aliphatic index 114.17

Grand average of hydropathicity (GRAVY) 0.242

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 7.252

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US 2012/0328692 A1

Patent Title Potent D-peptide antagonists of mdm2 and mdmx for anticancer therapy.

Other Iinformation Granted Patent Family: 8s / 8ex; Family Jurisdictions: CN, DK, US, EP, ES; Legal Status: Active; Application No: 16168397; Filed:May 4, 2016; Published: Jul 17, 2019; Earliest Priority: May 7, 2015; Granted: Jul 17, 2019

Other Published ID Not available