DPMI-δ-F

General Information


DCTPep ID  DCTPep01440

Peptide Name   DPMI-δ-F

Sequence  TAWYANFⓍKLLⓍ

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic construct

Type  Synthetic peptide

Classification

  

ACP Cancer targeted peptides Stapled Peptides MDM2/MDMX antagonists



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  MDM2, MDMX

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(8) and Ⓧ (12) are cross-linked by hydrocarbon stapling

N-terminal Modification  Not available

C-terminal Modification  Not available

Other Modification  Ⓧ(8)=(S)-2- (4'-pentenyl)alanine or (R)-2- (4'- pentenyl)alanine; Ⓧ(12)=(S)-2- (4'-pentenyl)alanine or (R)-2- (4'- pentenyl)alanine

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US20120328692A1

Patent Title  Potent D-peptide antagonists of mdm2 and mdmx for anticancer therapy.

Other Iinformation  Granted Patent Family: 8s / 8ex; Family Jurisdictions: CN, DK, US, EP, ES; Legal Status: Active; Application No: 16168397; Filed:May 4, 2016; Published: Jul 17, 2019; Earliest Priority: May 7, 2015; Granted: Jul 17, 2019

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.