Sequence 1 from Patent US 20120328692
General Information
DCTPep ID DCTPep01443
Peptide Name Sequence 1 from Patent US 20120328692
Sequence TAWYANFEKLLR
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic construct
Type Synthetic peptide
Classification
ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Not available
C-terminal Modification Not available
Other Modification None
Chiral L
Physicochemical Information
Formula C72H106N18O18
Absent amino acids CDGHIMPQSV
Theoretical pI 8.26
Acidic residues 1
Basic residues 2
Polar residues 3
Molecular weight (Average) 1511.74
Molecular weight (Monoisotopic) 1510.79
Common amino acids AL
Net charge 1
Instability index (II) 25.35
Aliphatic index 81.67
Grand average of hydropathicity (GRAVY) -0.358
Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 4.624
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 2012/0328692 A1
Patent Title Potent D-peptide antagonists of mdm2 and mdmx for anticancer therapy.
Other Iinformation Granted Patent Family: 8s / 8ex; Family Jurisdictions: CN, DK, US, EP, ES; Legal Status: Active; Application No: 16168397; Filed:May 4, 2016; Published: Jul 17, 2019; Earliest Priority: May 7, 2015; Granted: Jul 17, 2019
Other Published ID Not available