Peptide Libraray

Sequence 63 from Patent US 20120328692

General Information

DCTPep ID DCTPep01463

Peptide Name Sequence 63 from Patent US 20120328692

Sequence TSFAEYWNLLSP

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin Synthetic construct

Type Synthetic peptide

Classification

ACP

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Not available

Disulfide/Other Bond Not available

N-terminal Modification Not available

C-terminal Modification Not available

Other Modification None

Chiral L

Physicochemical Information

Formula C68H94N14O20

Absent amino acids CDGHIKMQRV

Theoretical pI 4.00

Acidic residues 1

Basic residues 0

Polar residues 5

Molecular weight (Average) 1427.58

Molecular weight (Monoisotopic) 1426.68

Common amino acids LS

Net charge -1

Instability index (II) 47.42

Aliphatic index 73.33

Grand average of hydropathicity (GRAVY) -0.075

Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 4.896

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US 2012/0328692 A1

Patent Title Potent D-peptide antagonists of mdm2 and mdmx for anticancer therapy.

Other Iinformation Granted Patent Family: 8s / 8ex; Family Jurisdictions: CN, DK, US, EP, ES; Legal Status: Active; Application No: 16168397; Filed:May 4, 2016; Published: Jul 17, 2019; Earliest Priority: May 7, 2015; Granted: Jul 17, 2019

Other Published ID Not available