IDP-H14-CPP

General Information


DCTPep ID  DCTPep01527

Peptide Name   IDP-H14-CPP

Sequence  RRRRRRRRVKLVNLXFATLREXVP

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetics

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
H-5B, epithelial small cell lung cancer lung cancer EC50≈7.5 μM MTT assay Not available Patent
NCI-H187 Lung small cell carcinoma; Small cell lung cancer EC50≈7.5 μM MTT assay Not available Patent
NCI-H510A Lung small cell carcinoma; Small cell lung cancer EC50≈7.5 μM MTT assay Not available Patent
NCI-H82 Lung small cell carcinoma; Small cell lung cancer EC50≈7.5 μM MTT assay Not available Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=—(CH2)6—CH═CH—(CH2)3— (for the cases NS10, NS16 and Na05) links both Xs radicals in each sequence

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US 2021/0230226 A1

Patent Title  Anticancer Peptides

Other Iinformation  Patent Application; Family: 8s / 8ex; Family Jurisdictions: CN, EP, CA, JP, AU, WO, US, KR; Legal Status: Pending; Application No: 201816634067; Filed: Jul 24, 2018; Published: Jul 29, 2021; Earliest Priority: Jul 25, 2017

Other Published ID  AU2018305923A1  CA3070874A1  CN111263768A  EP3658576A1  JP2020528458A  KR20200032183A  WO2019020649A1 




DCTPep is developed by Dr.Zheng's team.